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KMID : 0379520100260010053
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한국독성학회지
2010 Volume.26 No. 1 p.53 ~ p.59
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Mouse Single Oral Dose Toxicity Study of DHU001, a Polyherbal Formula
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Roh Seong-Soo
Ku Sae-Kwang
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Abstract
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This study was conducted to obtain acute information of the oral dose toxicity of DHU001, a polyherbal formula in male and female mice. In order to calculated 50% lethal dose (LD??) and approximate lethal dose (LD), test material was once orally administered to male and female ICR mice at dose levels of 2000, 1000, 500, 250 and 0 (vehicle control) ㎖/㎏ (body weight). The mortality and changes on body weight, clinical signs, gross observation, organ weight and histopathology of principle organs were monitored 14 days after treatment with DHU001. We could not find any mortalities, DHU001 treatment-related clinical signs, changes on the body and organ weights, gross and histopathological findings. The results obtained in this study suggest that LD?? and approximate LD in mice after single oral dose of DHU001 were considered over 2000 ㎎/㎏ in both female and male mice.
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KEYWORD
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DHU001, Polyherbal formula, Single oral dose toxicity, Mice, Histopathol
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